Pharmaceutical and biotechnology

WSP understands the challenges that the pharmaceutical industry is facing with R&D pipeline issues, the reduction in the cost of goods after manufacturing, regulatory reforms, and environmental concerns.



Our clients can be reassured by the fact that our consultants, engineers, and project managers have previously worked in the industry and have first-hand experience with the challenges you face. As a company, we have more than 50 years of experience supporting the pharmaceutical industry. We understand your business drivers and will bring inspired new ideas to your projects. Our teams work with pharmaceutical clients worldwide during the strategic planning stage, providing site master planning, concept studies, feasibility studies, and front end design. 

When you have secured capital funding, we can put together a multidisciplinary team to deliver a full Engineering, Procurement, Construction Management, and Validation (EPCMV) offering. Our international presence enables us to build you the best project team using our consultants and engineers from our Pharmaceutical Process Engineering Centre of Excellence and other global pharmaceutical hubs. Our industry leaders and our local experts can integrate with your team to ensure complete collaboration with your supply chain.

Our pharmaceutical support does not end when a capital project is completed: we have teams of engineers who work constantly on site, providing both operational and business improvement services. Not only do we deliver this support using alliance partnerships to ensure that you get the highest level of flexibility and value, we also provide the ongoing benefits of our international pharmaceutical expertise applied at site level.

Our team also provides detailed support for environmental, health, safety, sustainability, and energy requirements management. We offer an extensive suite of services from strategic support to meet sustainability challenges, planning support for new developments, as well as assistance in meeting the full range of safety and environmental requirements, including process safety, design safety review, major accident hazard management, and emissions control and permitting. WSP also has a group of top tier international experts who support pharmaceutical sector clients with product stewardship and product safety requirements, including REACH chemicals policy and hazard classifications.

Whether streamlining automation processes for pandemic preparedness, developing a concept study and capital investment plan for a complex multiproduct plant, or refurbishing existing facilities without disrupting ongoing operations, our rigorous yet flexible approach has earned the trust of diversified and non-diversified multinational clients such as GlaxoSmithKline and AstraZeneca, and local clients, while yielding numerous project successes and awards.

Procurement to Production

Our extensive portfolio of projects has encompassed design, engineering, project management, construction, and consultancy for:

  • Research and development facilities
  • Laboratories
  • High-level containment laboratories
  • Production and packaging facilities
  • Formulation and dosage facilities
  • Warehousing and logistics
  • Infrastructure and support facilities
  • Flexible facilities
  • Medical devices
  • Process intensification, process modelling, and facility improvements

Industry Recognition

Our expertise has been recognised by world-leading institutions, including:

  • The International Society of Pharmaceutical Engineers (ISPE), Facility of the Year 2013 Award for the Equipment Innovation for the Med-Immune Automation Upgrade project.
  • European Construction Institute (ECI), Case Study Project of the Year 2012: we delivered value-enhancing practice using ECI-ACTIVE principles for the effective storage of Pfizer’s high-value pharmaceutical products.

High-Quality Services at All Project Phases: Pre-Investment to Operational Handover

From research and development to commercial realization and full-scale manufacture, we provide integrated multidisciplinary engineering that encompasses consultancy, design, engineering, project and construction management, and commissioning and validation services. Our rigorous yet flexible approach has earned the trust of diversified and non-diversified multinationals such as GlaxoSmithKline and AstraZeneca, as well as renowned research facilities and institutes.

Strategic and Front-End Consulting Solutions to Meet Operational and Manufacturing Needs 

We offer technical expertise and timely and sustainable solutions to help our clients address concerns with compliance, operating costs and capital investments, asset location and manufacturing efficiency, and facility and equipment readiness to meet future business and production requirements. We can provide strategic advice on upgrading and redeveloping existing facilities to acquiring sites in new geographical regions, conducting full life cycle cost analysis as well as insightful analysis on rapidly-changing technologies that are driving drug development and lean manufacturing operations.

Our robust business process enables us to assist clients to shortlist, analyze and appraise options, assessing both non-financial benefits and risks.

  • Pre-feasibility and Feasibility studies
  • Funding and Investment appraisal 
  • Assets integrity management
  • Capital Program management
  • Business and strategic planning
  • Concept design / master planning 
  • FEED studies
  • Process engineering
  • Fluid flow analysis
  • Process flowsheets
  • Basic and detailed engineering
  • Engineering, procurement, and construction management (EPCM)
  • Project and construction management
  • Commissioning 
  • Validation
  • Building Information Modelling (BIM)
     
 

Review and Selection of Equipment and Technology for Bulk and Secondary Manufacturing Plants, R&D, Warehouse and Infrastructure Support Facilities

With scientific change and the evolution of new diseases and medical treatments, pharmaceutical and biotechnology clients frequently require facilities with well-designed, contained material follow, volume/capacity and production flexibility, transferrable analytical technologies, good manufacturing practices, all the while meeting stringent health and safety regulations. 

We have extensive expertise in the design, engineering and construction management of bio/pharmaceutical manufacturing plants, research and development centres, clean rooms, specialized laboratories and controlled environments (including the highest containment levels and biological safety levels), as well as the design and specification of equipment, integration of new process equipment and modifications to existing systems, without disrupting ongoing production activities.

  • Formulation and dosage facilities (solid, liquid, vial and inhalers)
  • Sterile suites and packaging
  • Research and development facilities
  • Laboratories
  • High-containment laboratories and facilities
  • Clean rooms
  • Aseptic suites 
  • Flexible facilities
  • Production and packaging facilities
  • Medical devices
  • Containment and process safety
  • Laboratory and clean room design
  • cGMP
  • Specialty testing
  • Quality assurance
  • Scanning facilities
  • Architectural and engineering design
  • Process intensification
  • Process modelling
  • Automation
  • Software development
  • Refrigeration
     

Commissioning, Qualification and Validation Services to Ensure Compliance 

We work with clients at start-up to ensure facilities are compliant with GMP and regulatory agency requirements, and through our qualification and validation services use advanced risk-based approaches and tools to authenticate and ensure that everything - processes, utilities, manufacturing equipment, ventilation systems and temperatures, humidity, airflows, water quality and supply chain, among others - performs smoothly and meets client specifications. 

  • Integrated commissioning and qualification (ICQ) 
  • Validation master plan (VMP)
  • Validation protocol format
  • Design qualification (DQ)
  • Installation qualification (IQ)
  • Operational qualification (OQ)
  • Performance qualification (PQ) 
  • Good automated manufacturing practice (GAMP)
  • Current good manufacturing practice (cGMP) review
  • Continued process verification (CPV)
  • Pre-Operational Verifications 
  • Commissioning and Startup
  • Training
  • Technical audits and due diligence

Health, Safety Environment and Quality Management

Our team also provides detailed support for environmental, health, safety, sustainability, and energy requirements management. As no two clients are alike, neither are their projects.  We offer an extensive suite of services from strategic support to meet sustainability challenges, planning support for new facility and manufacturing developments, as well as assistance in meeting the full range of safety and environmental requirements, including process safety, design safety review, major accident hazard management, and emissions control and permitting.

WSP also has a group of top tier international experts who support clients in the pharmaceutical and biotech supply chain with product stewardship and product safety requirements, including REACH chemicals policy and hazard classifications.

  • Safety design reviews
  • Hazard studies including HAZOP
  • Hazard analysis (HAZAN)
  • SWIFT and What-If studies
  • CHAZOPs
  • SIL (safety integrity level) analysis
  • Hazardous area classification and DSEAR studies